Study of pain perception under negative emotions and its large-scale brain network dynamics in adolescents with non-suicidal self-injury

作者：Yang Zhou, Dongdong Zhou, Zhengyong Zhang, Huiyu Jia, Fang Chen, Liuyi Ran, Xiaorong Chen, Li Wan, Yijia Wang, Wo Wang · 发表于：Frontiers in Psychiatry · 年份：2025 · DOI：10.3389/fpsyt.2025.1582971 · 被引用次数：4 · 研究领域：Suicide and Self-Harm Studies、Mental Health Research Topics、Mental Health via Writing

Background: Previous studies have indicated that negative emotions are one of the primary causes of non-suicidal self-injury (NSSI) behavior. This study focuses on examining the characteristics of large-scale brain network dynamics associated with pain perception in NSSI adolescents following experiences of negative emotions. Methods: A total of 44 adolescents with Major Depressive Disorder (MDD) and NSSI (MDD+NSSI group), 21 MDD adolescents without NSSI (MDD group), and 25 healthy controls (HC group) were recruited. Two emotional conditions (neutral and negative) were established, followed by the simulation of pain conditions using ice water stimulation, while electroencephalogram (EEG) signals were recorded using a 64-channel EEG system. Statistical analysis was conducted using mixed-design repeated measures analysis of variance, with multiple comparisons corrected using the Bonferroni method. Results: In the MDD+NSSI group, after sadness induction, the duration, time coverage of microstate A, and the transition rate from microstate B→A during the Cold Pressor Test (CPT) were significantly higher compared to neutral emotion induction. Conversely, the occurrence frequency of microstate B decreased markedly. Under neutral emotion induction, the MDD group exhibited higher occurrence frequency of microstate A and transition rate from microstate D→A than the HC group. In contrast, the occurrence frequency, coverage of microstate B, and transition probabilities from microstates C...