Diagnosis of Primary Open-Angle Glaucoma and Mental Health Status

作者：Mae O. Gordon, Feng Gao, John Burkland, James D. Brandt, Julia B. Huecker, J. Philip Miller, Pradeep Y. Ramulu, Michael A. Kass, Ocular Hypertension Treatment Study Group · 发表于：JAMA Ophthalmology · 年份：2025 · DOI：10.1001/jamaophthalmol.2025.1374 · 被引用次数：5 · 研究领域：Glaucoma and retinal disorders、Ophthalmology and Visual Impairment Studies、Corneal surgery and disorders

Importance: Some patients may become stressed when they are informed they have developed glaucoma. Clinicians should be aware that informing patients of the diagnosis of glaucoma might be associated with a reduction in the patient's mental health. Objective: To test whether mental health status as assessed by the National Eye Institute's Visual Function Questionnaire-25 (VFQ) decreases in patients with ocular hypertension after the diagnosis of early primary open-angle glaucoma (POAG). Design, Setting, and Participants: This cohort study was a post hoc analysis of prospective data from The Ocular Hypertension Treatment Study (OHTS) phase 1 and 2 among all participants with ocular hypertension who developed early POAG and had completed a VFQ within 2 years before and within 2 years after POAG diagnosis. The VFQ was administered every 2 years between January 2001 and December 2008. Propensity-matched participants with ocular hypertension who did not develop POAG over the same period were selected as controls. This analysis was conducted between March 7, 2024, and March 20, 2025. Main Outcome Measures: The main outcome was change in VFQ mental health score before and after POAG diagnosis in the POAG group compared with change over the same period in matched controls who did not develop POAG. Results: Fifty participants developed POAG and met criteria for inclusion (mean [SD] age, 67.9 [9.2] years; 21 [42%] female; and 17 [34%] Black). There were 100 matched OHTS control particip...