Neutrophil Percentage to Albumin Ratio Is Associated With In‐Hospital Mortality in Patients With Acute Type A Aortic Dissection

作者：Xuecui Zhang, Lingyu Lin, Yanchun Peng, Sailan Li, Xizhen Huang, Liangwan Chen, Yanjuan Lin · 发表于：Journal of Clinical Hypertension · 年份：2025 · DOI：10.1111/jch.70067 · 被引用次数：6 · 研究领域：Aortic Disease and Treatment Approaches、Aortic aneurysm repair treatments、Cardiac, Anesthesia and Surgical Outcomes

The neutrophil percentage to albumin ratio (NPAR) has been associated with prognosis of various cardiovascular diseases, but its role in acute type A aortic dissection (AAAD) mortality remains unclear. The aim of this study was to investigate the relationship between preoperative NPAR and in-hospital mortality in AAAD patients. Clinical data from patients who underwent AAAD surgery at the Cardiac Medical Center of Fujian Province between January 2020 and April 2024 were retrospectively analyzed. Patients were categorized into three groups based on NPAR tertiles. Univariate and multivariate logistic regression analyses were employed to identify factors contributing to in-hospital mortality. The predictive performance of NPAR was assessed using ROC curve analysis. The results revealed that out of 813 AAAD patients meeting the inclusion criteria, 137 (16.9%) died in hospital. Multivariate logistic regression analysis indicated that compared to the low tertile group, the odds ratios (95% CI) for in-hospital mortality in the middle and high tertile groups were (OR 3.041, 95% CI: 1.502-6.158, p = 0.002) and (OR 6.586, 95% CI: 3.324-13.049, p<0.001), respectively. Additionally, cardiopulmonary bypass time (OR 1.010, 95% CI: 1.007-1.013, p<0.001) and mechanical ventilation time (OR 1.115, 95% CI: 1.082-1.150, p<0.001) were also independently associated with in-hospital mortality in AAAD patients. The area under the curve for NPAR was 0.708 (95% CI: 0.676-0.739) (p<0.001), with an opt...