Practical perspectives on addressing hepatotoxicity during clinical candidate selection

作者：Adrian S. Ray · 发表于：Expert Opinion on Drug Metabolism & Toxicology · 年份：2025 · DOI：10.1080/17425255.2025.2516048 · 被引用次数：1 · 研究领域：Drug-Induced Hepatotoxicity and Protection、Liver Disease Diagnosis and Treatment、Liver Disease and Transplantation

Drug-induced liver injury (DILI) results in the failure of many drug candidates. The issue is compounded by the often delayed and idiosyncratic nature of DILI resulting in failure coming later in d...