Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study

作者：Sooji Lee, Seung Ha Hwang, Seoyoung Park, Yejun Son, Soeun Kim, Hyeon Jin Kim, Jaeyu Park, Hyesu Jo, Kyeongmin Lee, Jiyeon Oh, Min Seo Kim, Damiano Pizzol, Lee Smith, Jinseok Lee, Ho Geol Woo, Hayeon Lee, Dong Keon Yon · 发表于：Circulation · 年份：2025 · DOI：10.1161/circulationaha.125.073086 · 被引用次数：21 · 研究领域：Long-Term Effects of COVID-19、COVID-19 Clinical Research Studies、Pharmacological Receptor Mechanisms and Effects

BACKGROUND: Despite the significant global impact of the COVID-19 pandemic, limited studies have investigated the long-term cardiovascular sequelae of SARS-CoV-2 infection, particularly among Asian populations. This large-scale, population-based binational cohort study with long-term follow-up aimed to investigate the association between SARS-CoV-2 infection and the risk of cardiovascular events. METHODS: We used binational, large-scale, and population-based cohorts, including a Korean nationwide cohort (K-CONV-N [Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service cohort]; discovery cohort; n=18 989 129) and a Japanese nationwide cohort (Japan Medical Data Center; validation cohort; n=12 218 680). Individuals aged 20 years or older were included from January 1, 2020, to December 31, 2022. We assessed the long-term risk of incident cardiovascular outcomes after SARS-CoV-2 infection. The primary outcome was the risk of cardiovascular diseases based on International Classification of Diseases, Tenth Revision code diagnosis. After propensity score–based overlap weighting, Cox proportional hazard models were used to estimate adjusted hazard ratios for cardiovascular outcomes. We assessed the time attenuation effect of cardiovascular outcomes after SARS-CoV-2 infection. Multiple subgroup analyses were conducted by 16 cardiovascular outcomes, COVID-19 severity, vaccination, and SARS-CoV-2 strain. RESULTS: In the overlap-weighted discovery cohort, ...