Defect-Boosted Piezoelectric and Nanozymatic Synergetic Catalysis for Deep Bacterial Abscess Therapy

作者：Chao Peng, Wenting Wu, Huixiang Huo, Jing Li, Erkang Wang · 发表于：ACS Nano · 年份：2025 · DOI：10.1021/acsnano.5c05806 · 被引用次数：23 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Nanoparticles: synthesis and applications

Piezocatalytic therapy, distinguished by its superior tissue penetration under ultrasound activation and its low dependence on the oxygen concentration for generating multiple reactive oxygen species (ROS), has emerged as a promising strategy for deep abscess treatment. However, its efficacy remains constrained by a suboptimal bandgap, weak piezoelectric responses, and inadequate surface-active sites. To address these limitations, a facile Ru-atom doping strategy is first proposed using the Bi 4 O 5 Br 2 -based nanosystem (Bi 4 O 5 Br 2 @Ru) to tailor the bandgap and boost the piezo- and enzyme-like catalysis. The Ru dopants induce lattice distortions and elevate oxygen vacancies simultaneously, thereby enhancing piezoelectric responses while conferring peroxidase (POD)- and catalase (CAT)-like enzymatic activities. Under ultrasound excitation, the piezoelectric field optimizes the conduction band alignment of Bi 4 O 5 Br 2 @Ru, enhancing its POD-like activity to generate multiple ROS including ·OH, 1 O 2, and ·O 2 – . The mixed Ru (III/IV) valence states in Bi 4 O 5 Br 2 @Ru induce glutathione depletion, thereby further enhancing the oxidative stress capacity to combat biofilms. The enhanced CAT-like activity further alleviates hypoxia within biofilm microenvironments. RNA transcriptomic analysis confirms that Bi 4 O 5 Br 2 @Ru disrupts energy metabolism by interfering with the tricarboxylic acid cycle. The dual-modality therapy leverages doping engineering to seamlessly com...