The association between metal exposure in follicular fluid and PCOS risk in reproductive-aged women: Mediating Roles of LH/FSH ratio and androgens

作者：Xin Wang, Xueting Lai, Chenke Pan, Tao Yin, Wei Zhu, Xinyue Zhu, Jian Chen, Chunmei Liang, Dongmei Ji · 发表于：Ecotoxicology and Environmental Safety · 年份：2025 · DOI：10.1016/j.ecoenv.2025.118473 · 被引用次数：6 · 研究领域：Heavy Metal Exposure and Toxicity、Trace Elements in Health、Pregnancy and Medication Impact

The associations between trace elements levels and the risk of polycystic ovary syndrome (PCOS), particularly main contributor and their joint effect, are limited and elusive. In this case-control study, we involved 388 women with PCOS and 465 controls. We measured eighteen (aluminum, titanium, vanadium, chromium, manganese, iron, cobalt, copper, zinc, selenium, arsenic, cadmium, barium, mercury, lead, strontium, stannum, thallium) in follicular fluid through inductively coupled plasma-mass spectrometry (ICP-MS). Based on the multi-step statistical analysis including quantile g-computation (Q-gcomp), logistic regression model, orthogonal partial least squares discriminant analysis (OPLS-DA), random forest (RF) model and weighted quantile sum (WQS) regression, the top three essential trace elements among the 18 elements significantly associated with PCOS risk were cobalt (Co), stannum (Sn) and manganese (Mn), the top three heavy metals were lead (Pb), cadmium (Cd) and barium (Ba). The results of the BKMR model showed that mixtures of Pb, Cd and Ba were positively associated with the risk of PCOS, mixtures of Co, Sn and Mn were negatively associated with the risk of PCOS, mixtures of these six trace elements were negatively associated with the risk of PCOS at high concentrations, mixtures of 18 trace elements was negatively associated with the risk of PCOS. It states clearly that exposure to trace elements is associated with a decreased risk of PCOS, with trace essential elemen...