Integration of SERS with cutting-edge technologies for enhanced detection of drug-resistant microorganisms and optimized drug susceptibility testing

作者：Shuo Zheng, Qian Wang, Tuotuo Zhang, Xinwei Zhang, Hanying Wang, Nanke Cheng, Yuhan Gao, Zhuoran Hu, Sheng Qiu, Lihui Zhao, Junrong Li, Yao Sun · 发表于：Coordination Chemistry Reviews · 年份：2025 · DOI：10.1016/j.ccr.2025.216828 · 被引用次数：8 · 研究领域：Biosensors and Analytical Detection、Bacterial Identification and Susceptibility Testing、Spectroscopy Techniques in Biomedical and Chemical Research

The escalating issue of microbial resistance poses a significant threat to human health. Therefore, there is an increasing need for the development of new types of rapid detection and drug susceptibility testing (DST) methods to inform clinical treatment decisions. Currently, the detection of drug-resistant microorganisms and the assessment of drug susceptibility predominantly rely on complex biological techniques. While these methods offer high reliability, their application is hindered by the involvement of sophisticated machinery and intricate operational procedures, creating a high barrier to widespread use. Moreover, these methods often suffer from limitations such as insufficient detection sensitivity and the inability to perform simultaneous multiple analyses effectively. Although surface-enhanced Raman scattering (SERS) presents unique advantages, it still faces inherent challenges when used in isolation. This review focuses on recent advancements in the sensitive detection of drug-resistant microorganisms, drug-resistant genes, and rapid DST, particularly through the integration of SERS with other cutting-edge technologies. It aims to provide a broader perspective for future research in this area.