Synthesis, structural characterization, and antimicrobial activity of Zn(cloxyquin) 2 : towards harnessing zinc intoxication and immune response restoration to combat Staphylococcus aureus and Mycobacterium tuberculosis

作者：Khalil Mudarmah, Nalin Abeydeera, Guanyu Chen, Wjdan Jogadi, Jeanette A. Krause, Jonathan M. Budzik, Songping D. Huang · 发表于：Dalton Transactions · 年份：2025 · DOI：10.1039/d4dt02895c · 被引用次数：6 · 研究领域：Synthesis and Biological Evaluation、Synthesis and biological activity、Multicomponent Synthesis of Heterocycles

Cloxyquin, also known as 5-chloro-8-hydroxyquinoline, exhibits antimicrobial properties and can act as an effective Zn ionophore to harness Zn intoxication to kill Staphylococcus aureus and Mycobacterium tuberculosis .