Faecalibacterium langellae sp. nov. isolated from human faeces

作者：Adeline Ang Li Xuan, Véronique Robert, Atsushi Hisatomi, Masahiro Hirasaki, Shintaro Maeno, Moriya Ohkuma, Mitsuo Sakamoto, Jean‐Marc Chatel, Akihito Endo · 发表于：INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · 年份：2025 · DOI：10.1099/ijsem.0.006804 · 被引用次数：3 · 研究领域：Gut microbiota and health、Oral microbiology and periodontitis research、Bacterial Identification and Susceptibility Testing

A corrigendum of this article has been published full details can be found at 10.1099/ijsem.0.006838 The genus Faecalibacterium is one of the major butyrate-producing bacteria in the human gut. Due to its production of beneficial metabolites and reduced populations in diseased patients, it is regarded as a potential biomarker of healthy gut microbiota. Strains Collection Nationale de Cultures de Microorganismes (CNCM) I-4540 and CNCM I-4541 were isolated from faeces of a healthy elderly and a healthy adult respectively. In this study, we conducted a taxonomic analysis of these strains. Phylogenetic analyses based on 16S rRNA gene and rpoA gene sequences revealed that the two strains belong to the genus Faecalibacterium . A core gene phylogenetic tree further supported their phylogenetic placement. CNCM I-4540 shared an average nucleotide identity (ANI) value of 96.7% and a digital DNA–DNA hybridization (dDDH) value of 74.3% with Faecalibacterium taiwanense HLW78 T , indicating that CNCM I-4540 should be classified as F. taiwanense . In contrast, CNCM I-4541 did not exhibit ANI or dDDH values above the species threshold for any known species within the genus Faecalibacterium . These findings indicate that CNCM I-4541 represents a novel species within the genus Faecalibacterium , for which the name Faecalibacterium langellae sp. nov. is proposed. The type strain is CNCM I-4541 T (=CIP 112513 T =JCM 39552 T ).