The Impact of Prehabilitation on Patient Outcomes in Oesophagogastric Cancer Surgery: Combined Data from Four Prospective Clinical Trials Performed Across the UK and Ireland

作者：Sowrav Barman, Beth Russell, Robert Walker, William Knight, Cara Baker, Mark Kelly, James Gossage, Janine Zylstra, Greg Whyte, Joshua W. Pate, Jesper Lagergren, Mieke Van Hemelrijck, Mike Browning, Sophie Allen, Shaun R. Preston, Javed Sultan, Pritam Singh, Timothy Rockall, William B. Robb, Róisín Tully, Lisa Loughney, Jarlath Bolger, Jan Sørensen, Chris Collins, Paul Carroll, Claire Timon, Mayilone Arumugasamy, Thomas J. Murphy, Noel McCaffrey, Michael P. W. Grocott, Sandy Jack, Denny Levett, Tim Underwood, Malcolm West, Andrew Davies · 发表于：Cancers · 年份：2025 · DOI：10.3390/cancers17111836 · 被引用次数：3 · 研究领域：Cancer survivorship and care、Nutrition and Health in Aging、Enhanced Recovery After Surgery

Background: Prehabilitation is increasingly being used in patients undergoing multimodality treatment for oesophagogastric cancer (OGC). Most studies to date have been small, single-centre trials. This collaborative study sought to assess the overall impact of prehabilitation on patient outcomes following OGC surgery. Methods: Data came from four prospective prehabilitation trials conducted in the UK or Ireland in patients undergoing multimodality treatment for OGC. The studies included three randomised and one non-randomised clinical trial, each comparing a prehabilitation intervention group to controls. The prehabilitation interventions included aerobic training delivered by exercise physiologists alongside dietetic input throughout the treatment pathway. The primary outcome was survival (all-cause and disease-specific mortality). Secondary outcomes were differences in complications, cardio-respiratory fitness (changes in VO2 peak and anaerobic threshold (AT)), chemotherapy completion rates, hospital length of stay, changes in body mass index, tumour regression and complication rates of anastomotic leak and pneumonia. Cox and logistic regression analysis provided hazard ratios (HR) and odds ratios (OR), respectively, with 95% confidence intervals (CI), adjusted for confounders. Results: Among 165 patients included, 88 patients were in the prehabilitation group and 77 patients were in the control group. All-cause and disease-specific mortality were not improved by prehabilit...