Dynamic changes in chromatin accessibility within one month of mouse intracerebral hemorrhage

作者：Rong Xiang, Kang Ouyang, Junmin Wang, Zhan Chen, Tao Jin, Xinru Zhang, Hu Zhang, Zhiyun Li, Luyao Wang, Ruoqi Ding, Chuanyu Liu, Jun Xie, Yong Hou, Jian Wang, Longqi Liu, Mingyue Wang · 发表于：iScience · 年份：2025 · DOI：10.1016/j.isci.2025.112815 · 被引用次数：2 · 研究领域：Epigenetics and DNA Methylation、Kruppel-like factors research、Intracerebral and Subarachnoid Hemorrhage Research

-regulatory elements (cCREs) across days 1, 3, 7, 14, and 28. Our results revealed disruptions in multiple super-enhancers in microglia and macrophages, along with a transition of reactive astrocytes from a protective to a neurotoxic state. We also observed a significant upregulation of genes involved in hypoxia response and lipid metabolism within the remyelination pathways post-ICH. This study provides crucial insights into the epigenetic changes that occur following ICH, laying a solid foundation for future research and potential therapeutic interventions.