Rapid SERS Analysis: From Laboratory to Real Sample

作者：Haoyu Guo, Shengfu Zhi, Zeyu Zhao, Tianchu Gao, Hao Ma, Si-Heng Luo, Wei Zhang, Ping Guo, Bin Ren, Zhong‐Qun Tian, Guokun Liu · 发表于：ACS Applied Materials & Interfaces · 年份：2025 · DOI：10.1021/acsami.5c05699 · 被引用次数：26 · 研究领域：Gold and Silver Nanoparticles Synthesis and Applications、Spectroscopy Techniques in Biomedical and Chemical Research、Laser-induced spectroscopy and plasma

On the 50th anniversary of the discovery of surface-enhanced Raman spectroscopy (SERS), numerous reviews highlighted SERS advancements from different aspects, such as the historical evolution, enhancement mechanisms, quantitative analysis, and medical applications. However, how to develop the rapid SERS analysis for real samples has rarely been summarized yet. This review highlights the following three pivotal steps in this direction: (1) establishing reliable and highly selectively sensitive SERS analysis in the laboratory; (2) developing rapid sample pretreatment; and (3) AI-enhanced qualitative and quantitative SERS analysis.