A minimalist self-assembly nanosystem for cancer immunotherapy via multiple immune activation

作者：Weizhe Xu, Shiyuan Wang, Jiayi Zhang, Fang Wang, Zhaogang Sun, Bei Liu, Jun Ye, Hongqian Chu · 发表于：Journal of Nanobiotechnology · 年份：2025 · DOI：10.1186/s12951-025-03464-1 · 被引用次数：3 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques

Abstract In recent years, anti-tumor immunity has emerged as a central focus in cancer research, with the rapid advancement of immunotherapy heralding a new era in cancer treatment. Despite the significant potential of immunotherapy, the use of single-agent approaches or limited combination therapies has not consistently yielded optimal therapeutic outcomes. The strategic and controlled integration of diverse immune activation techniques within a single nanoparticle, utilizing a straightforward and universal methodology, continues to present a substantial challenge. Self-assembly, as a simple synthesis method, offers the possibility of combining multiple therapeutic approaches through straightforward means. In this study, we developed a novel approach to construct a biocompatible nanosystem, named Cu-ICG-CpG-FA (CICF), which was synthesized through one-pot coordination-driven self-assembly of Cu 2+ ions, CpG oligonucleotides and indocyanine green (ICG), followed by a surface modification with folic acid. Folic acid, as a ligand, can bind to folic acid receptors expressed on the surface of tumor cells. Cu 2+ facilitates chemodynamic therapy (CDT) through the Fenton reaction. ICG serves as a therapeutic for photothermal therapy (PTT) and photodynamic therapy (PDT). Moreover, CDT and PTT/PDT can induce immunogenic cell death (ICD), which is further enhanced by the immune-stimulating effect of CpG, thereby improving the tumor immunosuppressive microenvironment. Therefore, CICF pr...