Molecular hybridization strategy - discovery of 2,3-diarylpyrazine derivatives as potent Skp2 inhibitors with improved anti-tumor activity and enhanced cisplatin sensitivity

作者：Kaizhao Hu, Kun Zhang, Rui-Hao Chui, Wenhui Qiu, Peipei Miao, Linlin Zhang, Mengying Ding, Qingjin Zhang, Bing Zhao, Xiaojing Shi, Hong-Min Liu · 发表于：European Journal of Medicinal Chemistry · 年份：2025 · DOI：10.1016/j.ejmech.2025.117788 · 被引用次数：5 · 研究领域：Ubiquitin and proteasome pathways、Cancer-related Molecular Pathways、Microtubule and mitosis dynamics