Visible-Light-Mediated Perfluoroalkylation/Thioetherification of [1.1.1]Propellane under Photocatalyst-Free Conditions

作者：Jiabin Shen, Liangfeng Yang, Ge Kai, Hao Xu, Chao Shen · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01773 · 被引用次数：28 · 研究领域：Fluorine in Organic Chemistry、Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions

Perfluoroalkyl-functionalized bicyclo[1.1.1]pentane (BCP) derivatives have garnered significant attention in pharmaceuticals due to their special physicochemical property; however, establishing convenient synthetic protocols for these fluorinated molecular frameworks continues to present substantial methodological challenges. Herein, we report a photocatalyst and additive-free perfluoroalkylation/thioetherification of [1.1.1] propellane with disulfide ether and perfluoroalkyl iodines. Such a photochemistry methodology utilizing an electron donor-acceptor (EDA) complex offers a green and novel way to obtain various BCP derivatives containing perfluoroalkyl and thioether groups with good functional group tolerance.