RETRACTED: Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis

作者：Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Lei Wang, Ziyi He, Linbo Shen, Chen Ma, Zixian Wang, Lingfeng Zeng, Bo Shuai · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1606753 · 被引用次数：8 · 研究领域：Bone Metabolism and Diseases、Bone health and osteoporosis research、Medicinal Plant Pharmacodynamics Research

Background: As a global public health problem, osteoporosis (OP) urgently requires better treatment strategies. This study systematically evaluated the synergistic effect of traditional Chinese medicine (TCM) compounds combined with conventional Western medicine (such as bisphosphonates and calcium) compared to Western medicine alone in the treatment of OP through a meta-analysis. Methods: Based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Measurement Tool for Systematic Review Assessment guidelines, databases such as PubMed and Embase were systematically searched (as of March 2025), and 13 randomized controlled trials (RCTs), involving a total of 2,403 patients, were included. Results: The integrated Chinese and Western medicine group showed significantly higher lumbar and femoral neck Bone mineral density (BMD) growth rates than the control group, alongside reduced pain visual analogue scale (VAS) scores. Mechanistically, the combination therapy synergistically modulated bone turnover markers: the bone resorption marker type I collagen C-terminal peptide (CTX-1) decreased (MD = -1.33, P = 0.05), the bone formation marker osteocalcin (OC) increased (MD = 15.56, P < 0.0001), suggesting dual regulation of osteoclast inhibition (e.g., via Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) suppression) and osteoblast activation (e.g., via Wnt/β-catenin signaling). Notably, Procollagen I N-Terminal Propeptide (P1NP) levels remained unchanged ...