Association between the ratio of triglycerides to high-density lipoprotein cholesterol and nocturnal hypertension: a cross-sectional study in a Chinese population

作者：Hezeng Dong, Zhaozheng Liu, Jinling Zhang, Ye Han, Jing Zhang, Xi Yang, Liping Chang, Yue Deng · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1474467 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Blood Pressure and Hypertension Studies、Heart rate and cardiovascular health

Background and objective: The ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) serves as a predictive indicator for metabolic syndrome and cardiovascular diseases. Simultaneously, nocturnal hypertension significantly increases the risk of target organ damage and cardiovascular events. However, the relationship between the TG/HDL-C ratio and nocturnal hypertension remains unclear. Therefore, the present study aimed to determine the efficacy of the TG/HDL-C ratio in predicting the occurrence of nocturnal hypertension and reducing related adverse events. Method: Our rigorous cross-sectional study, which included 749 participants who underwent 24-hour ambulatory blood pressure monitoring at the Cardiology Center of Changchun University of Chinese Medicine Affiliated Hospital, allowed us to determine the association between the TG/HDL-C ratio and nocturnal hypertension. We employed both univariate and multivariate logistic regression analyses to ensure the robustness of our findings. Logistic regression modeling was used to assess the independent predictive ability of TG/HDL-C for nocturnal hypertension while adjusting for confounders such as sex, age, BMI, and smoking status. Model performance was assessed by subject work characteristics (ROC) curves and area under the curve (AUC). Results: Among the 749 participants included in this study, 566 were identified with nocturnal hypertension. Univariate logistic regression analysis demonstrated that the TG/HD...