Distinct viral reservoirs and immune signatures in individuals on long-term antiretroviral therapy with perinatally acquired HIV-1

作者：Benjamin Bone, Nicola Cotugno, Chiara Pighi, Arianna Rotili, Seohyun Hong, Leah Carrere, Elena Morrocchi, Giuseppe Rubens Pascucci, Ce Gao, Nicole Colantoni, Weiwei Sun, Giovanna Leone, David R. Collins, Mpho J. Olatotse, Giovanna Del Principe, Toong Seng Tan, Mélanie Lancien, Alessia Neri, Libera Sessa, G. Olivieri, Kailey Shapiro, Isabelle Roseto, Catherine K. Koofhethile, Elena Emili, Stefania Bernardi, Ann Chahroudi, Paolo Giorgi Rossi, Bruce D. Walker, Xu G. Yu, Mathias Lichterfeld, Paolo Palma · 发表于：Cell Reports Medicine · 年份：2025 · DOI：10.1016/j.xcrm.2025.102150 · 被引用次数：14 · 研究领域：HIV Research and Treatment、Immune Cell Function and Interaction、HIV/AIDS Research and Interventions

T cell response. Collectively, our data suggest that long-term ART initiated in early life following perinatal transmission may facilitate an immune environment better equipped to restrict the HIV-1 reservoir.