Speckle contrast optical spectroscopy for cuffless blood pressure estimation based on microvascular blood flow and volume oscillations

作者：Ariane Garrett, Byungchan Kim, Nil Z. Gurel, Edbert J. Sie, Benjamin K. Wilson, Francesco Marsili, John P. Forman, Naomi M. Hamburg, David A. Boas, Darren Roblyer · 发表于：Biomedical Optics Express · 年份：2025 · DOI：10.1364/boe.560022 · 被引用次数：10 · 研究领域：Non-Invasive Vital Sign Monitoring、Optical Imaging and Spectroscopy Techniques、Hemodynamic Monitoring and Therapy

This work introduces high-speed (390 Hz) speckle contrast optical spectroscopy (SCOS) to enable simultaneous measurements of multi-anatomic site microvascular blood volume and flow oscillations. Simultaneous blood flow and volume waveforms were extracted at two wavelengths on the wrist and finger, in reflectance and transmission mode, respectively. Blood volume changes (also known as photoplethysmography, or PPG) were determined based on intensity oscillations. Blood flow information was determined based on dynamic light scattering information encoded in the 2D spatial speckle pattern after removal of stochastic and instrument noise. We extracted a wide array of temporal, shape-based, and frequency-domain features from each high-resolution waveform, as well as features that characterize the temporal relationships between these features. These features and their inter-relationships are determined by the dynamic biomechanical properties of peripheral microvasculature, including vascular compliance and resistance, which are key determinants of dynamic changes in systemic blood pressure (BP). In comparison to PPG alone, SCOS demonstrated a notable 31% improvement (p = 3.45 * 10 −7 ) in systolic BP estimation when integrated into subject-specific machine-learning models. The resulting errors were remarkably low (systolic BP: 0.06+/- 2.88 mmHg, diastolic BP: 0.09 +/-2.14 mmHg) across a wide range of BP variations (range SBP: 89–284 mmHg). This improvement was sustained several week...