Evidence from two rounds of Population HIV Impact Assessments of progress towards HIV epidemic control in adolescents aged 15–19 years in Eswatini, Lesotho, Malawi, and Zimbabwe: a cross-sectional study

作者：Chloe A. Teasdale, Rebecca Zimba, Andrea Hsiu Ling Low, Harriet Nuwagaba‐Biribonwoha, Felix Ndagije, Lyson Tenthani, Owen Mugurungi, Philip Kreniske, Elaine J. Abrams · 发表于：The Lancet Global Health · 年份：2025 · DOI：10.1016/s2214-109x(25)00106-8 · 被引用次数：6 · 研究领域：HIV/AIDS Research and Interventions、Adolescent Sexual and Reproductive Health、HIV, Drug Use, Sexual Risk

Background There are more than 1 million adolescents aged 15–19 years living with HIV globally. Using two rounds of the Population HIV Impact Assessments (PHIAs), we describe incidence, prevalence, and UNAIDS 95–95–95 testing, treatment, and viral load suppression (VLS) indicators for adolescents living with HIV in four countries in southern Africa over time. Methods In this multinational cross-sectional study, we analysed data from two PHIA rounds in Eswatini (2016–17 and 2021), Lesotho (2016–17 and 2020), Malawi (2015–16 and 2020–21), and Zimbabwe (2015–16 and 2020). PHIAs are surveys distributed to randomly selected households, and participants were eligible if they had slept in the house the night before, were legally competent, and gave consent. Adolescents aged 15–19 years received rapid antibody HIV testing and provided blood samples. HIV incidence was estimated with avidity assays. Adolescents living with HIV were considered to be on antiretroviral therapy (ART) if they had detectable antiretrovirals in their blood or reported taking ART. VLS was defined as viral load of less than 1000 copies per mL. Survey-weighted proportions of adolescents living with HIV with known HIV status, on ART (among those with known HIV status), and VLS (among those on ART) were compared across survey rounds using Rao–Scott χ 2 tests adjusted for study weights with jackknife variance. Findings A total of 11 343 adolescents participated in round 1 (5947 [52·4%] were female and 5396 [47·6%] ...