Association of sperm DNA fragmentation with higher miscarriage rates in non-male factor infertility reproductive cycles

作者：Hong‐Jeng Yu, Chun­yan Shi, Chaowu Zhan, Cheng Wang, Jie Chen · 发表于：Translational Andrology and Urology · 年份：2025 · DOI：10.21037/tau-2025-322 · 被引用次数：7 · 研究领域：Sperm and Testicular Function、Reproductive System and Pregnancy、Reproductive Biology and Fertility

Background: Although recurrent spontaneous abortion (RSA) is often attributed to maternal or unknown causes, emerging evidence suggests that sperm DNA integrity may also influence pregnancy outcomes. Traditional semen analysis fails to detect subtle chromatin abnormalities, particularly in men without apparent infertility. This study assessed the contribution of the sperm chromatin structure instability in men to RSA in southern Anhui, China, and examined its correlation with RSA. Methods: The experimental group comprised 438 males who visited the Department of Reproductive Medicine at the Second People's Hospital of Wuhu between January 2022 and October 2023 due to RSA in their spouses. The control group included 189 males whose spouses did not experience RSA (non-RSA). The DNA fragmentation index (DFI), standard parameters, and general data related to the sperm were collected and statistically analyzed. Results: The DFI was significantly elevated in the RSA group relative to the non-RSA group (P<0.05). DFI was positively correlated with age and negatively linked to the concentration, total motility, normal morphology, and progressive motility of the sperm (P<0.05). It had no correlation with semen volume, total sperm number, smoking, alcohol consumption, occupation, or sleep duration (P>0.05). Age was negatively associated with the normal forms, while occupation was negatively associated with progressive motility (P<0.05). The routine semen parameters remained consistent ac...