Accelerating Sono‐Piezoelectric Charge Transport for Antibacterial Therapy and Bone Regeneration by Metal‐Deficient TiO 2 Spin‐Polarization Effect

作者：Chaofeng Wang, Shuilin Wu, Congyang Mao, Liguo Jin, Hanpeng Liu, Yufeng Zheng, Chunyong Liang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Xiangmei Liu · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202503186 · 被引用次数：9 · 研究领域：Nanoplatforms for cancer theranostics、Bone Tissue Engineering Materials、Facial Trauma and Fracture Management

Abstract Sonodynamic therapy (SDT) is recognized as an effective method for treating deep tissue bacterial infections, but enhancing charge transfer to achieve efficient SDT remains a formidable challenge. Here, deficient TiO 2 (DTO) is fabricated and Barium titanate (BTO) heterojunction with oxygen vacancies (OVs) and abundant Ti 3+ species on a Ti substrate. The OVs in DTO not only narrow the band gap of TiO 2 but also expedite the transfer of surrounding electrons to Ti 3+ . Meanwhile, the spin‐polarization effect induced by the unpaired spin electrons in Ti atoms can expedite the transfer of ultrasonic piezoelectric charges in BTO, enhancing surface sonocatalytic efficiency. Consequently, the DTO/BTO with US irradiation can eradicate 99.82% of Staphylococcus aureus and inhibit biofilm formation. Additionally, the microcurrent generated by ultrasound‐excited DTO/BTO enhanced mitochondrial fusion and promoted osteoblastic differentiation. The successful application of this ultrasound‐mediated DTO/BTO in treating bone infection defects offers an effective antibiotic‐free therapeutic strategy for deep‐seated infections.