Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines

作者：Lu Wang, Yanhong Sun, Meiling Yan, Lihua Wang, Yiyang Wang, Mengmeng Zhang, Qian Li, Huangan Wu, Jinyao Liu, Chunhai Fan · 发表于：Nano-Micro Letters · 年份：2025 · DOI：10.1007/s40820-025-01789-y · 被引用次数：2 · 研究领域：Immunotherapy and Immune Responses、Mast cells and histamine、Vagus Nerve Stimulation Research

Abstract Immunization has long played essential roles in preventing diseases. However, the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet. Here, we describe the use of acupoint delivery of nanovaccines (ADN) to elicit dual-niche immunological priming. ADN can simultaneously stimulate mast cell-assisted maturation of dendritic cells at the acupoint and enable direct delivery of nanovaccines into the draining lymph nodes. We demonstrate that ADN not only provokes antigen presentation by lymph node-resident CD8α + dendritic cells, but also induces the accumulation of nanovaccines in B-cell zones, amplifying antigen-specific cytotoxic T lymphocyte responses and immunoglobulin G antibody expression in draining lymph nodes. ADN also generates systemic immune responses by causing immune memory and preventing T-cell anergy in the spleen. Further supported by evoking effective antitumor responses and high-level antiviral antibodies in mice, ADN provides a simple yet versatile platform for advanced nanovaccination.