Evaluating the efficacy of fruquintinib versus regorafenib and trifluridine/tipiracil in treating advanced metastatic colorectal cancer: A match-adjusted indirect comparison.

作者：Shukui Qin, Jin Li, Rui‐Hua Xu, Lin Shen, Jianmin Xu, Yuxian Bai, Lei Yang, Yanhong Deng, Zhendong Chen, Haijun Zhong, Hongming Pan, Weijian Guo, Yongqian Shu, Ying Yuan, Jian-Feng Zhou, Nong Xu, Tianshu Liu, Dong Ma, Changping Wu, Ying Cheng · 发表于：Journal of Clinical Oncology · 年份：2025 · DOI：10.1200/jco.2025.43.16_suppl.e15550 · 被引用次数：1 · 研究领域：Colorectal Cancer Treatments and Studies、Lung Cancer Treatments and Mutations、Cancer Treatment and Pharmacology

e15550 Background: Fruquintinib (fru), regorafenib (reg), and trifluridine/tipiracil (TAS102) are 3 rd line treatments for patients with previously treated metastatic colorectal cancer (mCRC). Further evidence is required to support clinical decision-making in treating mCRC. In the absence of head-to-head studies, we performed a match-adjusted indirect comparison (MAIC) to evaluate the weighted OS and PFS of fru versus the published OS and PFS of reg and TAS102. Methods: Individual participant-level data (IPD) from FRESCO (NCT02314819) and the published aggregate data (AgD) from the Chinese Subgroup of CONCUR (CONCURsub) (NCT01584830) and TERRA (NCT01955837) were used. According to the eligible criteria of the two AgD trials, 14 IPDs with colon and rectum (6 in fru arm and 8 in placebo arm) were excluded in MAIC with TERRA trial. The baseline covariances of IPD were re-weighted to match those of the AgDs separately. Hazard ratios (HRs) were estimated to compare the weighted OS and PFS of fru with the published OS and PFS of reg or TAS102. Due to the poor overlap of the placebo arms between FRESCO and CONCURsub, unanchored MAIC was conducted to compare fru with reg. Anchored MAIC was performed to compare fru with TAS102. Results: All identified covariances of IPD were well-matched with those of AgDs. The effective sample size (ESS) of IPD after matching and the comparative effect estimates for OS and PFS are presented in the table. Fru showed a numerically favorable weighted O...