Association between wildfire-dominated PM 2.5 exposure and non-small cell lung cancer survival in California.

作者：Surbhi Singhal, Jonathan W. Riess, Mariela Alaniz, Sean Raffuse, Shuchi Gulati, Theresa H.M. Keegan, Irva Hertz‐Picciotto, Shehnaz K. Hussain · 发表于：Journal of Clinical Oncology · 年份：2025 · DOI：10.1200/jco.2025.43.16_suppl.10520 · 被引用次数：2 · 研究领域：Air Quality and Health Impacts

10520 Background: Wildfire emissions include hazardous constituents, including fine particulate matter ≤2.5 μm in diameter (PM 2.5 ). PM 2.5 exposure is associated with increased risk of lung cancer. However, the impact of wildfire-dominated PM 2.5 exposure on survival after non-small cell lung cancer (NSCLC) diagnosis is unknown. Methods: We identified all patients diagnosed with NSCLC in the California Cancer Registry between 2017-2020. Daily PM 2.5 was estimated over the same period by random forest regression fusing official air quality monitoring, satellite observations, meteorological modeling, predictive smoke modeling, and low-cost sensors, producing a consensus estimate of PM 2.5 over a 1-square kilometer grid across California. We quantified PM 2.5 exposure by averaging daily PM 2.5 in the 12 months after NSCLC diagnosis based on home address at time of diagnosis. Adjusted cox-proportional hazards regression was used to estimate the hazard ratio (HR) for cancer-related death associated with PM 2.5 exposure following NSCLC diagnosis overall and stratified by smoking status and stage at diagnosis. We adjusted for patient demographics, comorbidity, body mass index, rural residence, and COVID-19 time-period. Results: Among 18,585 patients with NSCLC, the mean age was 70.4 years (standard deviation [SD] 10.5) and the mean PM 2.5 concentration was 9.8 μg/m 3 (SD 2.0). Higher mean daily PM 2.5 in the 12 months after NSCLC diagnosis was associated with 20% increased hazard ...