Synthesis of 5‐Arylselenyluracils via Bromide‐Catalyzed Selective C( sp 2 )‐H Selenylation of Uracils

作者：Zhouting Zeng, Feng Zhao, Huaixin Wei, Mingming Yu, Jinhui Cai · 发表于：Asian Journal of Organic Chemistry · 年份：2025 · DOI：10.1002/ajoc.202500415 · 被引用次数：15 · 研究领域：Organoselenium and organotellurium chemistry、Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods

Abstract Herein, an efficient method for the synthesis of 5‐arylselenyluracils via bromide‐catalyzed selective C( sp 2 )‐H selenylation of uracils using boronic acid and elemental selenium as the selenyl source was successfully developed. This method proceeded smoothly for a series of arylboronic acids and uracils under metal‐free and strong oxidant‐free conditions. This protocol offered simple catalytic conditions, high efficiency, good functional group compatibility, easy operation, and easy scalable. Furthermore, the mechanistic studies suggested that this transformation was possibly undergone via a radical pathway.