Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis

作者：Stener Nerland, Cláudia Barth, Kjetil Nordbø Jørgensen, Laura A. Wortinger, Josefina Castro‐Fornieles, Covadonga M. Díaz‐Caneja, Joost Janssen, Celso Arango, Gisela Sugranyes, Inmaculada Baeza, Fabrizio Piras, Nerisa Banaj, Federica Piras, Simone Elia, Daniela Vecchio, M. Lundberg, Hannes Bohman, Bjørn Rishovd Rund, Elena de la Serna, Adriana Fortea, Christian K. Tamnes, Lars T. Westlye, Runar Elle Smelror, Dimitrios Andreou, Erik Jönsson, Matthew J. Kempton, Shuqing Si, Marinos Kyriakopoulos, Carrie E. Bearden, Kristen Laulette, Saül Pascual‐Diaz, Anne‐Kathrin Fett, Katherine H. Karlsgodt, Lydia Krabbendam, Peter Kochunov, Sophia I. Thomopoulos, Neda Jahanshad, Anthony James, Sophia Frangou, Anne M. Myhre, Nils Eiel Steen, Ole A. Andreassen, Paul M. Thompson, Ingrid Agartz · 发表于：Molecular Psychiatry · 年份：2026 · DOI：10.1038/s41380-026-03641-0 · 被引用次数：2 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Schizophrenia research and treatment

Abstract Cortical brain morphology in early-onset psychosis (EOP; age of onset < 19 years) is poorly understood, partly due to recruitment constraints linked to its low incidence. We pooled T1-weighted magnetic resonance imaging (MRI) data from 387 adolescents with EOP (mean age=16.1±1.5; 49.6% female) and 338 healthy controls (CTR; mean age=15.8±1.9, 54.4% female) from nine research sites worldwide. Using harmonized processing protocols with FreeSurfer, we extracted cortical brain metrics from 34 bilateral regions. Univariate regression analysis revealed widespread lower bilateral cortical thickness (left/right hemisphere: d =-0.36/-0.31), surface area (left/right: d =-0.42/-0.41), cortical volume (left/right: d =-0.58/-0.56), and Local Gyrification Index (LGI; left/right: d =-0.39/-0.52) in EOP relative to CTR. Subgroup analyses showed broader and more pronounced case-control differences in early-onset schizophrenia for area, volume, and LGI. We found no associations with antipsychotic medication use, illness duration, age of onset, or positive symptoms. Negative symptoms were related to smaller left lingual volumes (partial r =-0.21; p FDR =0.014) and antidepressant users had smaller area ( d =-0.43; p FDR =0.034) and volume ( d =-0.50; p FDR =0.003) of the right rostral anterior cingulate compared to non-users. Cortical alterations in EOP showed a similar pattern to those observed in prior studies on adults with schizophrenia (SCZ; r =0.62) and bipolar disorders (BD; r...