Exploratory biomarker analysis of trastuzumab deruxtecan (T-DXd) vs physician’s choice of chemotherapy (TPC) in HER2-low/ultralow, hormone receptor–positive (HR+) metastatic breast cancer (mBC) in DESTINY-Breast06 (DB-06).

作者：Rebecca Dent, Giuseppe Curigliano, Xichun Hu, Kan Yonemori, Carlos H. Barrios, Hans Wildiers, William Jacot, Seock-Ah Im, Joohyuk Sohn, Jun Ke, Chindu Govindaraj, Maria Schwaederlé, Robert McEwen, Danielle Carroll, Aditya Bardia · 发表于：Journal of Clinical Oncology · 年份：2025 · DOI：10.1200/jco.2025.43.16_suppl.1013 · 被引用次数：12 · 研究领域：HER2/EGFR in Cancer Research、Advanced Breast Cancer Therapies、Breast Cancer Treatment Studies

1013 Background: DB-06 (NCT04494425), a Phase 3, randomized, open-label study, demonstrated a clinically meaningful progression-free survival (PFS; 13.2 vs 8.1 months [hazard ratio: 0.64]) benefit with T-DXd vs TPC (capecitabine, nab-paclitaxel, or paclitaxel) in patients with HR+, HER2-low (immunohistochemistry [IHC] 1+ or IHC 2+ / in situ hybridization–negative) or -ultralow (IHC 0 with membrane staining) mBC after ≥1 endocrine-based therapy (primary data cutoff: March 18, 2024). Here, we report an exploratory circulating tumor DNA (ctDNA) analysis based on baseline genomic status. Methods: Baseline ctDNA profiling in blood samples was assessed via Guardant OMNI 500-gene liquid biopsy assay. In total, 625 patients had evaluable ctDNA samples and putative tumor content, and comprised the biomarker evaluable population (BEP) presented herein. Baseline characteristics and efficacy outcomes were evaluated in key genomic subgroups (PI3K pathway, ESR1 m, BRCA1/2 m), including confirmed objective response rate (cORR) and PFS, both by blinded independent central review. Results: Genomic alterations were observed in 45.0% (PI3K pathway, n=281), 51.5% ( ESR1 m, n=322), and 7.7% ( BRCA1/2 m, n=48) of patients. The median PFS (mPFS) for each mutational subgroup was 13.2 (T-DXd) and 7.1 (TPC) months (PI3K pathway), 11.3 (T-DXd) and 7.0 (TPC) months ( ESR1 m), and 21.4 (T-DXd) and 5.6 (TPC) months ( BRCA1/2 m). T-DXd improved PFS and cORR outcomes compared with TPC across all mutational ...