Engineered nanoparticle transformations: Rethinking toxicity in water

作者：Mikołaj Feculak, Susana Loureiro, Jason C. White, Baoshan Xing, Kevin C.‐W. Wu, Mohamed S. Sheteiwy, Yanzheng Gao, Patryk Oleszczuk, Izabela Jośko · 发表于：Nano Today · 年份：2025 · DOI：10.1016/j.nantod.2025.102804 · 被引用次数：25 · 研究领域：Nanoparticles: synthesis and applications、Graphene and Nanomaterials Applications、Nanomaterials for catalytic reactions

The burgeoning production and utilization of engineered nanoparticles (ENPs) in recent years has precipitated the intentional and inadvertent discharge of ENPs into the environment, where undergo different transformations. Extensive research has investigated the mechanisms underlying the environmental transformations of metal-based ENPs, with a focus on alterations in the properties of their transformation products. It is widely recognized that ENP-biota interactions are influenced by various ENP characteristics, such as size, shape, surface area, chemical composition, surface charge, and chemistry. As a result of transformations, changes in ENP properties are anticipated to affect biotic interactions, including cellular recognition and trafficking, thus impacting organismal responses. This hypothesis has only recently been subjected to experimental scrutiny, mainly within simplified ENP-organism systems. Major studies indicate that the acute toxicity of transformed ENPs is largely driven by the rate and yield of metal ion release, similar to pristine ENPs. However, when transformations reduce ENP dissolution, they may enhance environmental persistence, rendering other toxicity mechanisms more significant. We meticulously examine available data on the toxicity of various transformed ENPs, aiming to systematically assess the actual responses of aquatic biota concerning altered ENP properties and differing environmental factors. In this context, we highlight scenarios involving...