Vendor‐agnostic 3D multiparametric relaxometry improves cross‐platform reproducibility

作者：Shohei Fujita, Borjan Gagoski, Jon‐Fredrik Nielsen, Maxim Zaitsev, Yohan Jun, Jaejin Cho, Xingwang Yong, Quentin Uhl, Pengcheng Xu, Eugene Milshteyn, Imam Ahmed Shaik, Qiang Liu, Qingping Chen, Onur Afacan, John E. Kirsch, Yogesh Rathi, Berkin Bilgiç · 发表于：Magnetic Resonance in Medicine · 年份：2025 · DOI：10.1002/mrm.30566 · 被引用次数：7 · 研究领域：Advanced MRI Techniques and Applications、Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications

Abstract Purpose To address the unmet need for a cross‐platform, multiparametric relaxometry technique to facilitate data harmonization across different sites. Methods A simultaneous T 1 and T 2 mapping technique, 3D quantification using an interleaved Look–Locker acquisition sequence with a T 2 preparation pulse (3D‐QALAS), was implemented using the open‐source vendor‐agnostic Pulseq platform. The technique was tested on four 3 T scanners from two vendors across two sites, evaluating cross‐scanner, cross‐software version, cross‐site, and cross‐vendor variability. The cross‐vendor reproducibility was assessed using both the vendor‐native and Pulseq‐based implementations. A National Institute of Standards and Technology/International Society for Magnetic Resonance in Medicine system phantom and three human subjects were evaluated. The acquired T 1 and T 2 maps from the different 3D‐QALAS runs were compared using linear regression, Bland–Altman plots, coefficient of variation (CV), and intraclass correlation coefficient (ICC). Results Pulseq‐QALAS demonstrated high linearity ( R 2 = 0.994 for T 1 , R 2 = 0.999 for T 2 ) and correlation (ICC = 0.99 [0.98–0.99]) against temperature‐corrected NMR reference values in the system phantom. Compared to vendor‐native sequences, the Pulseq implementation showed significantly higher reproducibility in phantom T 2 values (CV, 2.3% vs. 17%; p < 0.001), and improved T 1 reproducibility (CV, 3.4% vs. 4.9%; p = 0.71, not significant). The P...