Economic and sustainable revolution to facilitate one-carbon biomanufacturing

作者：Chenyue Zhang, Qiang Fei, Rongzhan Fu, Maximilian Lackner, Yongjin J. Zhou, Tianwei Tan · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-60247-w · 被引用次数：43 · 研究领域：Microbial Metabolic Engineering and Bioproduction、Biofuel production and bioconversion、Bioeconomy and Sustainability Development

One-carbon (C1) biomanufacturing serves as a substitute for fossil-based feedstocks, aiming to de-fossilize chemical production and foster a circular carbon economy by recycling waste greenhouse gases. Here, we review the key economic and technical barriers associated with the commercialization of C1 biomanufacturing through case studies. Additionally, a viable roadmap to enhance cost competitiveness is unveiled, underscoring its potential to facilitate carbon neutrality as scalable and sustainable alternatives to traditional chemical production. The implementation of one-carbon (C1) biomanufacturing is limited to laboratory or pilot scales. Here, the authors highlight the economic and technical challenges associated with scaling up C1 biomanufacturing and propose strategies to address these challenges.