Organ Donation for Research Biobanking Among Historically Marginalized Racial and Ethnic Groups

作者：Camilo Toro, Oseiwe Eromosele, David Flynn, Andrew A. Wilson, Darrell N. Kotton, Timothy M. Hughes, Jesse D. Moreira, Wendy S. Post, Alain G. Bertoni, Emelia J. Benjamin, Deepa M. Gopal, Jessica L. Fetterman · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.12133 · 被引用次数：4 · 研究领域：Organ Donation and Transplantation、Ethics in Clinical Research、Pluripotent Stem Cells Research

Importance: Research biobanks of human cells and tissues, particularly tissues accessible only after death, are crucial for advancing the understanding of human pathophysiological function. Research biobanks are bereft of tissues from individuals of diverse races and ethnicities, thus limiting the generalizability of biobank findings. Objective: To evaluate the barriers and facilitators to participation in postmortem brain donation for research among individuals from historically marginalized races and ethnicities. Evidence Review: The published literature in PubMed, Embase, Web of Science, and PsycINFO databases was searched from 1973 to January 1, 2024. Studies that were written in English that involved adult participants (aged ≥18 years) and explored attitudes, perceptions, and beliefs on solid organ donation were included. Studies in which organ donation was for transplant and not for research, studies examining pediatric organ donation, narratives or perspectives, and studies that did not examine attitudes or beliefs toward organ donation were excluded. Two authors independently coded and performed a thematic analysis of eligible studies. Findings: Eighteen studies met the inclusion criteria, which involved 12 124 participants across multiple self-reported races and ethnicities (eg, Black or African American, Chinese, Hispanic or Latiné, and White). Most studies (16 [89%]) evaluated perceptions, attitudes, and beliefs among Black or African American and Hispanic or Latin...