Boron Catalysis-Enabled Regioselective Ring-Retentive Hydrosilylation of Methylenecyclopropanes

作者：Rui Lin, Min Ou, Ni Qian, Xianmao Liu, Zhen Song, Xinmiao Huang, Wei Yao, Yaqi Chen, Jinxing Long, Weiqi Song, Yuanhong Ma · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01720 · 被引用次数：4 · 研究领域：Organoboron and organosilicon chemistry、Asymmetric Hydrogenation and Catalysis、Catalytic Cross-Coupling Reactions

Herein, we report the highly regioselective ring-retentive hydrosilylation of methylenecyclopropanes (MCPs) with hydrosilanes by a B(C 6 F 5 ) 3 catalyst. The catalytic protocol affords an atom-efficient route for the synthesis of silylcyclopropanes, featuring 100% atom-efficiency, broad substrate scope (42 examples), mild conditions, and high regio-, and chemoselectivity. The current metal-free catalytic hydrosilylation also provides a complementary pathway for the synthesis of structurally diverse organosilicon compounds from MCPs over transition metal-catalyzed variants.