A tough semi-dry hydrogel electrode with anti-bacterial properties for long-term repeatable non-invasive EEG acquisition

作者：Dongyang Wang, Hailing Xue, Xia Long, Zongqi Li, Yubo Zhao, Xinan Fan, Kai Sun, Huanan Wang, Timo Hämäläinen, Chi Zhang, Fengyu Cong, Yanhua Li, Fei Song, Jiaqi Lin · 发表于：Microsystems & Nanoengineering · 年份：2025 · DOI：10.1038/s41378-025-00908-4 · 被引用次数：14 · 研究领域：EEG and Brain-Computer Interfaces、Neuroscience and Neural Engineering、Photoreceptor and optogenetics research

Non-invasive brain–computer interfaces (NI-BCIs) have garnered significant attention due to their safety and wide range of applications. However, developing non-invasive electroencephalogram (EEG) electrodes that are highly sensitive, comfortable to wear, and reusable has been challenging due to the limitations of conventional electrodes. Here, we introduce a simple method for fabricating semi-dry hydrogel EEG electrodes with antibacterial properties, enabling long-term, repeatable acquisition of EEG. By utilizing N-acryloyl glycinamide and hydroxypropyltrimethyl ammonium chloride chitosan, we have prepared electrodes that not only possess good mechanical properties (compression modulus 65 kPa) and anti-fatigue properties but also exhibit superior antibacterial properties. These electrodes effectively inhibit the growth of both Gram-negative (E. coli) and Gram-positive (S. epidermidis) bacteria. Furthermore, the hydrogel maintains stable water retention properties, resulting in an average contact impedance of <400 Ω measured over 12 h, and an ionic conductivity of 0.39 mS cm−1. Cytotoxicity and skin irritation tests have confirmed the high biocompatibility of the hydrogel electrodes. In an N170 event-related potential (ERP) test on human volunteers, we successfully captured the expected ERP signal waveform and a high signal-to-noise ratio (20.02 dB), comparable to that of conventional wet electrodes. Moreover, contact impedance on the scalps remained below 100 kΩ for 12 h, wh...