Photo- and Copper-Catalyzed Enantioselective Oxidation of Benzylic C(sp 3 )–H Bonds

作者：Li Fu, Xianming Liu, Jia‐Bin Pan, Ling Dai, Yin Yang, Li‐Jun Xiao, Chao Fan, Qi‐Lin Zhou · 发表于：Journal of the American Chemical Society · 年份：2025 · DOI：10.1021/jacs.5c04142 · 被引用次数：14 · 研究领域：Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions、Synthesis and Catalytic Reactions

Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp 3 )–H bonds using N -hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions and does not require excess substrates or oxidants. The oxidation products can be readily transformed into chiral benzylic alcohols or hydroxylamines. Preliminary mechanism studies suggest that the oxidation reaction proceeds via a free radical mechanism.