The relationship between hemoglobin glycation index and the risk of cardiovascular disease in populations with diabetes or prediabetes: a population-based cohort study

作者：Zheng Wang, Fachao Shi, Long Wang, Caoyang Fang · 发表于：Diabetology & Metabolic Syndrome · 年份：2025 · DOI：10.1186/s13098-025-01754-0 · 被引用次数：3 · 研究领域：Advanced Glycation End Products research、Diabetes, Cardiovascular Risks, and Lipoproteins、Adipokines, Inflammation, and Metabolic Diseases

OBJECTIVE: The relationship between Glycated Hemoglobin Index (HGI) and cardiovascular disease (CVD) risk in individuals with diabetes or prediabetes remains unclear. Therefore, this study aims to investigate the relationship between baseline HGI and CVD risk in U.S. adults with diabetes or prediabetes. METHODS: This study analyzed data from 10,889 diabetic or prediabetic participants from the National Health and Nutrition Examination Survey (NHANES). Weighted multivariable regression analysis and subgroup analyses were employed to assess the relationship between HGI and CVD risk. Restricted cubic splines were used to explore nonlinear associations, along with threshold effect analysis and subgroup analyses. RESULTS: A total of 10,889 participants (mean age 52.82 years, 54.57% male) were included in this study. We observed a U-shaped relationship between HGI and the risk of cardiovascular disease (CVD) (P nonlinear < 0.0001), heart attack (P nonlinear = 0.0006), and congestive heart failure (CHF) (P nonlinear = 0.0001). The inflection points for HGI concerning CVD, heart attack, and CHF were - 0.140, -0.447, and - 0.140, respectively. When baseline HGI exceeded these thresholds, each unit increase in HGI was significantly associated with higher risks of CVD (OR: 1.34, 95% CI: 1.23-1.48), heart attack(OR: 1.34, 95% CI: 1.20-1.51), and CHF (OR: 1.39, 95% CI: 1.22-1.58).Subgroup analysis revealed significant differences in CHF risk associated with HGI across racial groups (inter...