ELEVATED SERUM BRAIN INJURY MARKERS CORRELATE WITH DISEASE FEATURES AND INTERFERONS IN CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

作者：Ganesh Ramanathan, Oscar Mwizerwa, Justine Ledochowski, Tala El Tal, Sarah I. Mossad, Ibrahim Mohamed, Joanna Law, Lawrence Ng, Paris Moaf, Asha Jeyanathan, Adrienne L. Davis, E. Ann Yeh, Linda T. Hiraki, Deborah L. Levy, Zahi Touma, Joan Wither, B Zapparoli, Ashley Danguecan, Andrea Knight · 发表于：The Journal of Rheumatology · 年份：2025 · DOI：10.3899/jrheum.2025-0390.o044 · 被引用次数：1 · 研究领域：Systemic Lupus Erythematosus Research

O044 / #255 Topic: AS05 - CNS Lupus ABSTRACT CONCURRENT SESSION 07: COGNITION IMPAIRMENT IN SLE – RECENT ADVANCEMENT AND EMERGING RESEARCH 23-05-2025 1:40 PM - 2:40 PM Background/Purpose Childhood-onset systemic lupus erythematosus (cSLE) involves interferon (IFN)-mediated inflammation emerging during the critical period of adolescent brain development. Neuropsychiatric lupus (NPSLE) manifests as syndromes like cognitive dysfunction, seizures, and psychiatric disorders, which negatively impact education, psychosocial functioning, and quality of life. While previous work indicates a type I IFN-α signature in cSLE, the levels of type II IFN-γ as well as the roles of both IFNs in the pathogenesis of brain inflammation have not been well established in literature. Moreover, clinicians face challenges diagnosing/treating brain inflammation in cSLE, due to suboptimal diagnostic tools. Neuronal/glial structural proteins may be useful biomarkers of brain injury in cSLE. We aimed to i) compare serum levels of brain injury markers and IFNs between children with cSLE and controls; and ii) investigate the relationship of brain injury markers to cSLE disease features and serum IFN levels. Methods We utilized prospectively-collected cross-sectional data from cSLE participants (ages 12-17 years) recruited from the Lupus Clinic at a Canadian tertiary children’s hospital from January 2020–December 2023, and age-, sex-matched healthy controls. Serum brain injury markers (serum neurofilament li...