Seroprevalence of Lyme Disease in Asian Human Populations: A Systematic Review and Meta-Analysis

作者：Jieqin Song, Yan Dong, Yu Zhang, Guozhong Zhou, Xinya Wu, Li Gao, Hanxin Wu, Li Peng, Jiaru Yang, Zhenhua Ji, Bingxue Li, Yuxin Fan, Jingjing Chen, Meixiao Liu, Jing Kong, Weijie Ma, Lei Zhong, Weijiang Ma, Aihua Liu, Bao FuKai · 发表于：Vector-Borne and Zoonotic Diseases · 年份：2025 · DOI：10.1089/vbz.2024.0092 · 被引用次数：6 · 研究领域：Vector-borne infectious diseases、Viral Infections and Vectors、Mosquito-borne diseases and control

Background: Lyme disease (LD, also known as Lyme borreliosis) is the most frequent tick-transmitted disease caused by the spirochete Borrelia in Europe and the United States. LD is distributed in the Northern Hemisphere, but the seroprevalence of LD in Asian human populations is unclear. Objectives: To investigate the seroprevalence of LD in Asian human populations. Data Sources: PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and other sources were searched for relevant studies with MeSH terms from their inception up to 20 June 2022. Study Eligibility Criteria: Cross-sectional studies with no language restrictions. Participants: Healthy people, at-risk people, and patients with suspected LD. Moreover, the seroprevalence of LD was diagnosed by laboratory diagnosis (nzyme-linked immunosorbent assays (ELISA)/Immunofluorescence assays (IFA) or/and two-tier testing) in human populations. Assessment of Risk of Bias: Risk of bias was rated using the Joanna Briggs Institute (JBI) standardized critical appraisal instrument for prevalence studies (Critical Appraisal Checklist for Analytical Cross-Sectional Studies). Methods of Data Synthesis: Seroprevalence and proportion of LD in human populations in Asia were obtained from the included studies. Two authors independently screened and selected studies according to our predefined criteria (PROSPERO CRD42022362029) and assessed their risk of bias. A third author was available for arbitrating discrepancies. ...