Association of Differences in Cystatin C‐ and Creatinine‐Based Estimated Glomerular Filtration Rate With Prevalence and Incidence of Stroke

作者：Xiaohua Shi, Jiayin Song, Fenglin Chen, Lingyu Zhang, Yuanmei Chen, Wanqi Xu, Chen Sheng, Zhiyuan Wu, XU Zhong-xin, Cancan Cui · 发表于：Journal of the American Heart Association · 年份：2025 · DOI：10.1161/jaha.124.039185 · 被引用次数：5 · 研究领域：Chronic Kidney Disease and Diabetes、Dialysis and Renal Disease Management、Renal and Vascular Pathologies

Background The intraindividual difference between the estimated glomerular filtration rates by cystatin C and creatinine (ie, eGFRdiff) is of clinical importance. This study aimed to investigate the cross‐sectional and longitudinal associations of eGFRdiff with stroke using nationally representative data from the CHARLS (China Health and Retirement Longitudinal Study). Methods This study included 11 869 participants (aged ≥45 years) from the CHARLS 2015 for the cross‐sectional analysis. A total of 11 553 participants free of stroke were recruited in 2015 as baseline and followed up to 2020 for the cohort analysis. The eGFRdiff was calculated by subtracting estimated glomerular filtration rate by serum creatinine from estimated glomerular filtration rate by serum cystatin C at baseline. Logistic regression models and Cox proportional hazards models were used to examine the cross‐sectional and longitudinal associations. Results The mean age of the participants was 60.3±9.6 years, and 5514 (46.5%) were men. According to the cross‐sectional analysis, a negative eGFRdiff was associated with a greater prevalence of stroke (odds ratio per 1 SD, 0.841 [95% CI, 0.741–0.955]). During a median follow‐up of 5.0 years, 838 individuals (7.3%) experienced incident stroke. A lower baseline eGFRdiff was associated with a greater risk of stroke onset (hazard ratio [HR] per 1 SD, 0.884 [95% CI, 0.817–0.955]). Compared with those in the midrange eGFRdiff group (from −15 to 15 mL/min per 1.73 m 2...