A tomato MIK2-clade receptor is involved in the perception of a Fusarium -derived elicitor

作者：Julian Maroschek, Yvonne Roesgen, Clemens Roessner, Simon Snoeck, Claus Schwechheimer, Cyril Zipfel, Ralph Hückelhoven · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2025 · DOI：10.1101/2025.05.22.655486 · 被引用次数：4 · 研究领域：Plant Disease Resistance and Genetics、Plant-Microbe Interactions and Immunity

Summary Plants continuously monitor their environment to adapt to threats affecting health and fitness. Cell-surface receptors detect conserved microbe-associated molecular patterns (MAMPs) or endogenous immunogenic signals to activate signaling pathways that induce broad-spectrum disease resistance, known as pattern-triggered immunity (PTI). In Arabidopsis thaliana , the leucine-rich repeat receptor kinase MIK2 emerged as a versatile receptor involved in perceiving endogenous SCOOP peptides as well as potential MAMPs derived from Fusarium and related fungi. While SCOOP perception appears restricted to Brassicales, the Fusarium -derived elicitor triggers PTI-responses across different plant lineages. Here, we demonstrate that Fusarium elicitor-responsiveness and MIK2-clade proteins are conserved among seed plants. We identified a tomato MIK2-clade receptor that shares At MIK2 properties in perceiving the Fusarium elicitor, but not SCOOPs. Tomato mutants lacking the receptor show compromised PTI-responses to the fungal elicitor and increased susceptibility to Fusarium oxysporum . By integrating AI-assisted structural prediction with experimental data, we identify conserved and variable residues in Arabidopsis and tomato MIK2-clade receptors that may underlie shared and lineage-specific recognition specificities. Together, these findings establish MIK2-clade receptors as immune surveillance modules that have undergone lineage-specific diversification, supporting a model in whic...