DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models

作者：Yanyu Zhong, Jin Ding, Fei Xia · 发表于：Archives of Gynecology and Obstetrics · 年份：2025 · DOI：10.1007/s00404-025-08048-w · 被引用次数：9 · 研究领域：Reproductive Biology and Fertility、Ovarian function and disorders、Sperm and Testicular Function

PURPOSE: To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies. RECENT FINDINGS: Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA methylation signatures as diagnostic biomarkers and therapeutic targets.