Multiple Organ Dysfunction Syndrome Associated With Pneumonia: A Retrospective Study With a Focus on Respiratory Failure

作者：Jie Zhou, Shunjin Fang, Jianfeng Zhu, Su Yao, Huifei Zhou · 发表于：British Journal of Hospital Medicine · 年份：2025 · DOI：10.12968/hmed.2024.0851 · 被引用次数：1 · 研究领域：Pneumonia and Respiratory Infections、Nosocomial Infections in ICU、Sepsis Diagnosis and Treatment

Aims/Background Pneumonia is a complex condition with rapid progression, often leading to multiple organ dysfunction syndrome (MODS), which significantly impacts patient quality of life and prognosis. This study aims to identify risk factors closely associated with the development of MODS by conducting a retrospective analysis of clinical data from 150 patients with pneumonia, providing insights for informing the prevention and treatment of pneumonia. Methods We recruited 150 patients with pneumonia admitted to Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University between 2019 and 2022. The patients were divided into two groups according to whether they had developed MODS: the non-MODS group (n = 100) and the MODS group (n = 50). Patients’ data, such as their demographic information, clinical characteristics, laboratory test results, treatment course and outcomes, were collected. Logistic regression analysis was conducted to determine the independent predictors of MODS occurrence. Results After propensity score matching, the baseline data of the two groups of patients presented no significant difference (p > 0.05). The predominant clinical and laboratory manifestations of both groups of patients were fever, cough, decreased arterial partial pressure of oxygen (PaO 2 ), as well as elevated white blood cell (WBC) count, C-reactive protein (CRP) level, and procalcitonin (PCT) level, but inter-group differences in these metrics were not statistically si...