All‐Cause Mortality and Suicide Mortality in Patients With Tic Disorder: An Entire Population Longitudinal Study in Taiwan

作者：Tien‐Wei Hsu, Wen‐Han Chang, Chih‐Ming Cheng, Shih‐Jen Tsai, Ya‐Mei Bai, Ju‐Wei Hsu, Kai‐Lin Huang, Tzeng‐Ji Chen, Chih‐Sung Liang, Mu‐Hong Chen · 发表于：Suicide and Life-Threatening Behavior · 年份：2025 · DOI：10.1111/sltb.70023 · 被引用次数：2 · 研究领域：Obsessive-Compulsive Spectrum Disorders、Psychosomatic Disorders and Their Treatments、Bipolar Disorder and Treatment

BACKGROUND: Few studies investigate cause-specific mortality in individuals with tic disorders. We aimed to examine all-cause, natural-cause, and unnatural-cause mortality in individuals with tic disorders. METHODS: Using the nationwide database of Taiwan from 2003 to 2017, we identified 50,018 patients with tic disorders and, using a ratio of 1:4, matched unaffected controls based on birth year and sex. Cause-specific mortality (i.e., natural cause, accident, and suicide mortality) and all-cause mortality were assessed between the two cohorts using time-dependent Cox regression models. RESULTS: After adjusting for demographics, individuals with tic disorders had increased likelihoods (reported as adjusted hazard ratio [aHR] with 95% confidence interval [CI]) of all-cause (1.14, 1.03-1.26), unnatural-cause (including accidents and suicides; 1.78, 1.43-2.23), and suicide mortality (3.09, 2.07-4.59) compared to controls. With additional adjustments for psychiatric comorbidities, the likelihood of all-cause, unnatural-cause, and suicide mortality remained significant. However, we did not find a higher natural cause mortality in patients with tic disorders compared to controls (1.02, 0.91-1.15). CONCLUSION: Individuals with tic disorders have a higher likelihood of unnatural causes and suicide mortality after adjusting for demographics, clinical characteristics, and psychiatric comorbidities. Our findings suggest that clinicians should routinely monitor both the physical and ment...