Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts

作者：Cody Z. Watling, Jessica L. Petrick, Barry I. Graubard, Xuehong Zhang, Matthew J Barnett, Julie E. Buring, Yu Chen, A. Heather Eliassen, Michael Gaziano, Jae H. Kang, Jill Koshiol, Wen‐Yi Huang, I‐Min Lee, Steven C. Moore, Lorelei A. Mucci, Marian L Neuhouser, Christina C. Newton, Julie R. Palmer, Lynn Rosenberg, Howard D. Sesso, Martha J. Shrubsole, Lesley Tinker, Matthew Triplette, Caroline Y. Um, Kala Visvanathan, Jean Wactawski‐Wende, Walter C. Willett, Fen Wu, Wei Zheng, Jonathan N. Hofmann, Mark P. Purdue, Peter T. Campbell, Dinesh Kumar Barupal, Katherine A. McGlynn · 发表于：Environmental Health Perspectives · 年份：2025 · DOI：10.1021/ehp.6c00400 · 被引用次数：13 · 研究领域：Per- and polyfluoroalkyl substances research、Toxic Organic Pollutants Impact、Fluorine in Organic Chemistry

Abstract BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) have been associated with numerous deleterious health outcomes, including liver damage. However, whether exposure to PFAS is associated with liver cancer risk remains unclear. METHODS: We conducted a matched nested case-control study among 12 prospective cohort studies located in the United States. Prediagnostic PFAS, namely, perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS), were measured from blood samples among 853 individuals who developed liver cancer and 853 matched control participants. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted conditional logistic regression for liver cancer risk by study-specific quartiles of concentrations and per 90th vs 10th percentile incremental increase. RESULTS: In the main multivariable-adjusted model, circulating PFOS, PFOA, and PFHxS levels were not associated with liver cancer risk (OR per 90th vs 10th percentile increase: 1.00, 95% CI: 0.79–1.28; 0.92, 0.73–1.15; and 0.95, 0.75–1.21, respectively). However, when analyses were stratified by sex, PFOA concentrations were positively associated with liver cancer risk in males (OR per 90th vs 10th percentile increase: 1.62 95% CI: 1.07–2.45), whereas an inverse association was observed among females (OR per 90th vs 10th percentile increase: 0.68, 0.50–0.92; p-interaction = 0.005). Analyses separating liver cancer subtypes, hepatocel...