Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial

作者：Yingsha Li, Qianran Wang, Yi Liu, Huijuan Li, Weijie Xia, Shaoyang Lin, Qian Yang, Alexandra Scholze, Zhigang Zhao, Hongbo He, Hexuan Zhang, Zhencheng Yan, Martin Tepel, Hui-Jun Mu, Zhiming Zhu, Daoyan Liu · 发表于：iScience · 年份：2025 · DOI：10.1016/j.isci.2025.112719 · 被引用次数：6 · 研究领域：Aldose Reductase and Taurine、Nitric Oxide and Endothelin Effects、Pharmacology and Obesity Treatment

= 83 were randomly enrolled and received either taurine (2.4 g/day) or placebo for 12 weeks. Compared to the placebo, taurine led to a significant reduction in systolic BP, and improvement of endothelium-dependent or -independent vasodilation and pulse wave velocity after taurine 12 weeks in patients with T2D. Taurine significantly inhibited the activation of platelet calcium influx in patients with T2D. Taurine may exert beneficial the effects on blood pressure and vascular dysfunction in patients with T2D.