Intramolecular Cyclopropanation of Alkene-Tethered CF 3 -Imidoyl Sulfoxonium Ylides: Synthesis of Cyclopropane-Fused Quinolines

作者：Ying Tang, W. LUO, Baoyi Liu, Yi Liu, Jun Ying, Xue-Tao Xu, Jin‐Bao Peng · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01563 · 被引用次数：8 · 研究领域：Fluorine in Organic Chemistry、Cyclopropane Reaction Mechanisms、N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

A metal-free intramolecular cyclopropanation of CF 3 -imidoyl sulfoxonium ylides with styrenes was developed, affording cyclopropane-fused quinolines. This strategy provides efficient access to diverse trifluoromethyl-substituted dihydro-1 H -cyclopropa[ c ]quinolines under mild, transition-metal-free conditions. Notably, the sulfoxonium ylide generation and subsequent cyclopropanation could proceed in a one-pot fashion, affording the products in good yields.