Diagnostic accuracy of [99mTc]pertechnetate scintigraphy in pediatric patients with suspected Meckel’s diverticulum: a 12-year, monocentric, retrospective experience

作者：Bo Li, Gao Jian, Xintao Ding, Xiali Li, Yue Yu, Long Ye, Xiaohui Wang, Xinyu Wu, Yongju Gao · 发表于：Frontiers in Medicine · 年份：2025 · DOI：10.3389/fmed.2025.1585313 · 被引用次数：7 · 研究领域：Gastrointestinal disorders and treatments、Congenital Diaphragmatic Hernia Studies、Diverticular Disease and Complications

Objective To assess the diagnostic accuracy of [ 99 m Tc]pertechnetate scintigraphy in pediatric patients with suspected Meckel’s diverticulum (MD). Methods A retrospective study was conducted on 94 pediatric patients who presented with symptoms suggestive of MD and underwent [ 99 m Tc]pertechnetate scintigraphy at Henan Provincial People’s Hospital between September 2012 and August 2024. For patients with high clinical suspicion and equivocal scintigraphy results, Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) or repeat scintigraphy was conducted. Hemoglobin levels were measured in all patients, and their correlation with MD was analyzed. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated by comparing scintigraphic results with surgical and histopathological findings. Results Among the 94 patients, 20 (21.3%) had positive [ 99 m Tc]pertechnetate scintigraphy, all confirmed as true positives through laparoscopic resection and histopathological examination. Of the 74 patients with negative scintigraphy results, 6 were found to be false negatives based on surgical findings, and 68 were confirmed as true negatives. Therefore, the sensitivity, specificity, PPV, and NPV were 76.9% (20/26), 100.0% (68/68), 100.0% (20/20), and 91.9% (68/74), respectively. The overall diagnostic accuracy was 93.6% (88/94). SPECT/CT was utilized in three cases, enhancing diagnostic preci...