Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

作者：Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin · 发表于：Med Research · 年份：2025 · DOI：10.1002/mdr2.70006 · 被引用次数：49 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Immunotherapy and Biomarkers、Radiomics and Machine Learning in Medical Imaging

ABSTRACT Intratumoral microorganisms within solid tumor TMEs significantly influence tumorigenesis and development by altering immune and metabolic patterns. Their diverse compositions and species contribute to the structural and functional heterogeneity of the TME, affecting tumor progression. Understanding the dual roles of these microbes in antitumor and protumor activities and their complex interactions with the TME enhances our knowledge of the mechanisms underlying tumorigenesis and development.