Brain structural and functional impairment network localization in obsessive–compulsive disorder

作者：Ya Tian, Wen‐Qing Shi, Qiuying Tao, Huiting Yang, Huirong Guo, Baohong Wen, Yarui Wei, Huafu Chen, Yong Zhang, Jingliang Cheng, Shaoqiang Han · 发表于：Journal of Psychiatry and Neuroscience · 年份：2025 · DOI：10.1503/jpn.240145 · 被引用次数：5 · 研究领域：Obsessive-Compulsive Spectrum Disorders、Functional Brain Connectivity Studies、Transcranial Magnetic Stimulation Studies

BACKGROUND: Numerous neuroimaging studies investigating the neural substrates of obsessive-compulsive disorder (OCD) have yielded inconsistent findings, and growing evidence suggests that psychiatric disorders are more accurately localized to brain networks rather than discrete brain regions. We sought to identify brain network localization in OCD. METHODS: We initially examined brain locations of structural and functional alterations among patients with OCD and healthy controls using neuroimaging studies. Employing a novel technique called functional connectivity network mapping (FCNM) and large-scale human brain connectome data, we mapped these damaged brain regions to 2 brain impairment networks in OCD. RESULTS: We included 62 neuroimaging studies involving 2578 patients with OCD and 2502 healthy controls. For FCNM, we used data from 556 healthy adults. Among patients with OCD, the grey matter volume (GMV) and resting-state activity impairment networks encompassed a broad range of brain regions, primarily involving the default mode, sensorimotor, and limbic networks, as well as the bilateral middle frontal gyrus and bilateral middle temporal gyrus. Additionally, the GMV impairment network specifically involved bilateral inferior frontal gyrus. LIMITATIONS: We used large-scale human brain connectome data from healthy people, rather than the samples clinically and demographically matched to the original study participants, to examine brain networks in OCD. CONCLUSION: Our st...